منابع مشابه
Genetics and ischaemic stroke.
Ischaemic stroke can be caused by a number of monogenic disorders, and in such cases stroke is frequently part of a multisystem disorder. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL), due to mutations in the NOTCH: 3 gene, is increasingly appreciated as a cause of familial subcortical stroke. The genetics and phenotypes of monogenic stroke...
متن کاملStroke and transient ischaemic attacks.
accounts for about 5% ofNHS hospital costs. Stroke is the commonest cause of severe physical disability. About 100 000 people suffer a first stroke each year in England and Wales. It is important to emphasise that around 20-25% of all strokes affects people under 65 years of age. The annual incidence of stroke is two per 1000.' About 10% of all patients suffer a recurrent stroke within one year...
متن کاملPosterior circulation ischaemic stroke.
There are important differences between posterior and anterior circulation stroke. The differences include the value of screening instruments, optimum diagnos‐ tic modalities, and clinical features (table). The face arm speech test (FAST), a widely used prehospital stroke recognition screening instrument, is less sensitive for detecting posterior circulation stroke than for anterior cir‐ culati...
متن کاملGenetics of ischaemic stroke.
Recent advances in genomics and statistical computation have allowed us to begin addressing the genetic basis of stroke at a molecular level. These advances are at the cusp of making important changes to clinical practice of some monogenic forms of stroke and, in the future, are likely to revolutionise the care provided to these patients. In this review we summarise the state of knowledge in is...
متن کاملSpontaneous ischaemic stroke lesions in a dog brain: neuropathological characterisation and comparison to human ischaemic stroke
BACKGROUND Dogs develop spontaneous ischaemic stroke with a clinical picture closely resembling human ischaemic stroke patients. Animal stroke models have been developed, but it has proved difficult to translate results obtained from such models into successful therapeutic strategies in human stroke patients. In order to face this apparent translational gap within stroke research, dogs with isc...
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ژورنال
عنوان ژورنال: BMJ
سال: 2007
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.38964.489051.80